FOR U.S. RESIDENTS ONLY AGE 18 AND OVER

Why TRADJENTA?

Along with diet and exercise, TRADJENTA:

Tradjenta can help your body produce more insulin and less sugar

Can help your body produce
more insulin and less sugar

Tradjenta® (linagliptin) can help lower your A1C

Can help lower
your A1C

Tradjenta® (linagliptin) provides the simplicity of once-a-day dosing

Provides simplicity of
once-daily dosing

TRADJENTA is a prescription medicine that is used along with diet and exercise to lower blood sugar in adults with type 2 diabetes.

TRADJENTA is not for people with type 1 diabetes or for people with diabetic ketoacidosis (increased ketones in the blood or urine).

If you have had inflammation of the pancreas (pancreatitis) in the past, it is not known if you have a higher chance of getting pancreatitis while
you take TRADJENTA.

HOW TRADJENTA
MAY HELP

Taking TRADJENTA, along with diet and exercise, can help change the direction of your blood glucose numbers.

Even when you're doing everything you can to eat well and get enough physical activity, your numbers may not be going in the direction you and your doctor want them to. But there are ways to help and you don't have to do it on your own.

TRADJENTA, along with diet and exercise, may be able to help.

It's a once-daily tablet that, along with a healthy diet and physical activity, can help improve blood sugar levels in adults with type 2 diabetes, and can help effectively lower your A1C levels.

TRADJENTA® (linagliptin) tablets is a prescription medicine that is used along with diet and exercise to lower blood sugar in adults with type 2 diabetes.

TRADJENTA is not for people with type 1 diabetes or for people with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had inflammation of the pancreas (pancreatitis) in the past, it is not known if you have a higher chance of getting pancreatitis while you take TRADJENTA.

TRADJENTA and metformin

In clinical studies, taking TRADJENTA with metformin resulted in a significant improvement of blood sugar and A1C levels than metformin alone. In clinical trials, TRADJENTA taken with metformin did not affect most people's weight, although weight gain may occur when used in combination with a medication called pioglitazone.

Read More +

HOW TRADJENTA Works

All type 2 diabetes medications work to help lower your blood sugar, but since no two people with diabetes are exactly alike and may respond differently to different treatments, what works for one person may not work for another. That's why there are many different classes of diabetes drugs, and each class works in a different way.

What is TRADJENTA?

TRADJENTA belongs to a class of drugs called DPP-4 inhibitors. DPP-4 inhibitors work by increasing hormones that stimulate your pancreas to produce more insulin and stimulate your liver to produce less glucose.

What TRADJENTA does

In other words, TRADJENTA, along with diet and exercise, can help your body produce more insulin and less sugar. Managing your sugar can mean a lower A1C – and that's an important goal for anyone with type 2 diabetes.

See How Tradjenta Works

TAKING TRADJENTA Every Day

Taking TRADJENTA, along with diet and exercise, can help get your
blood sugar and A1C headed in a different direction.

Take TRADJENTA once a day as your doctor tells you
ONCE A DAY

Take TRADJENTA once a day as your doctor tells you

Tradjenta can be taken with or without food
WITH OR WITHOUT FOOD

Taking TRADJENTA does not depend on your meal schedule

Do not double dose
DON’T DOUBLE DOSE

Only take one dose each day

If your doctor prescribed TRADJENTA to you:

  • Take TRADJENTA once each day, exactly as your doctor tells you to take it
  • Take TRADJENTA with or without food
  • If you miss a dose, take it as soon as you remember. If you do not remember until it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not take two doses of TRADJENTA at the same time

Your doctor may tell you to take TRADJENTA along with other diabetes medicines. Low blood sugar can happen more often when TRADJENTA is taken with certain other diabetes medicines, such as sulfonylurea or insulin. Tell your doctor if you take other medicines that can lower your blood sugar.

What to watch out for:

  • If you take too much TRADJENTA, call your doctor or Poison Control Center at 1‑800‑222‑1222 or go to the nearest hospital emergency room right away
  • When your body is under some types of stress, such as fever, trauma (such as a car accident), infection, or surgery, the amount of diabetes medicine that you need may change. Tell your doctor right away if you have any of these conditions and follow your doctor's instructions
  • Stay on your prescribed diet and exercise program while taking TRADJENTA
  • Check your blood sugar as your doctor tells you to
  • Store TRADJENTA at 59°F to 86°F (15°C to 30°C)
  • Keep TRADJENTA and all medicines out of the reach of children
Important Safety Information And Indication See More +

What is the most important information I should know about TRADJENTA?

Serious side effects can happen to people taking TRADJENTA, including inflammation of the pancreas (pancreatitis), which may be severe and lead to death. Before you start taking TRADJENTA, tell your doctor if you have ever had pancreatitis, gallstones, a history of alcoholism, or high triglyceride levels.

Stop taking TRADJENTA and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis.

Who should not take TRADJENTA?

Do not take TRADJENTA if you are allergic to linagliptin or any of the ingredients in TRADJENTA.

Symptoms of a serious allergic reaction to TRADJENTA may include rash, itching, flaking or peeling; raised red patches on your skin (hives); swelling of your face, lips, tongue and throat that may cause difficulty breathing or swallowing. If you have any symptoms of a serious allergic reaction, stop taking TRADJENTA and call your doctor or go to the emergency room right away.

What should I tell my doctor before using TRADJENTA?

Tell your doctor about all your medical conditions, including if you have or have had inflammation of your pancreas (pancreatitis).

Tell your doctor about all the medicines you take, including prescription and over‑the‑counter medicines, vitamins, and herbal supplements. TRADJENTA may affect the way other medicines work, and other medicines may affect how TRADJENTA works. Especially tell your doctor if you take

  • other medicines that can lower your blood sugar. If you take TRADJENTA with another medicine that can cause low blood sugar, such as sulfonylurea or insulin, your risk of getting low blood sugar is higher. The dose of your sulfonylurea or insulin may need to be lowered while you take TRADJENTA.
  • rifampin (Rifadin®, Rimactane®, Rifater®, Rifamate®)*, an antibiotic that is used to treat tuberculosis.

*These trademarks are owned by third parties not affiliated with TRADJENTA.

Tell your doctor if you are pregnant or planning to become pregnant or are breastfeeding or plan to breastfeed.

What are the possible side effects of TRADJENTA?

TRADJENTA may cause serious side effects, including

  • Inflammation of the pancreas (pancreatitis).
  • Low blood sugar (hypoglycemia), especially if you take TRADJENTA with another medicine that can cause low blood sugar. Signs and symptoms of low blood sugar may include headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, fast heartbeat, sweating, or feeling jittery.
  • Allergic (hypersensitivity) reactions can happen after your first dose or up to 3 months after starting TRADJENTA. Symptoms may include swelling of your face, lips, throat, and other areas on your skin; difficulty with swallowing or breathing; raised, red areas on your skin (hives); skin rash, itching, flaking, or peeling.
  • Joint pain. Some people who take medicines called DPP-4 inhibitors like TRADJENTA, may develop joint pain that can be severe. Call your doctor if you have severe joint pain.

The most common side effects of TRADJENTA include stuffy or runny nose, sore throat, cough and diarrhea.

These are not all the possible side effects of TRADJENTA. For more information, ask your doctor or pharmacist. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑10881‑800‑FDA‑1088.

What is TRADJENTA?

TRADJENTA is a prescription medicine that is used along with diet and exercise to lower blood sugar in adults with type 2 diabetes.

TRADJENTA is not for people with type 1 diabetes or for people with diabetic ketoacidosis (increased ketones in the blood or urine).

If you have had inflammation of the pancreas (pancreatitis) in the past, it is not known if you have a higher chance of getting pancreatitis while you take TRADJENTA.

TJ CONS lSI 31AUG2015

Please see Prescribing Information and Medication Guide.